Biochemical Alterations in Diabetic Neuropathy

Type 2 Diabetes mellitus is a disease which manifests with a variety of cardiovascular risk factors, including hypertension, dyslipidemia and overweight or obesity that contributes to development of long term complications termed diabetic related ailments. Diabetic peripheral neuropathy (DPN) is a debilitating condition affecting as many as one half of all patients with diabetes during the course of their disease. Several metabolic and vascular pathways have been identified as contributors to the pathogenesis of diabetic neuropathy. Diabetic neuropathy encompasses a wide range of clinical and subclinical syndromes from pain to complete loss of sensation. Metabolic and therapeutic approaches have focused on aldose reductase, poly (ADPRibose) polymerase, protein kinase C, advanced Glycation end products. Novel approaches to identify targets for treatment of diabetic peripheral neuropathy require cross links between molecular and computational biology methods.